纽约时报说它是腺病毒疫苗:
An adenovirus helps prime the immune system to fight the coronavirus.
www.nytimes.com
强生疫苗是根据该病毒的遗传学原理来构建刺突蛋白的。 但是,与存储在单链RNA中的辉瑞BioNTech和Moderna疫苗不同,强生疫苗使用双链DNA。
腺病毒内的DNA
研究人员将冠状病毒刺突蛋白的基因添加到另一种称为腺病毒26的病毒中。腺病毒是常见病毒,通常会引起感冒或类似流感的症状。 强生团队使用一种经过修饰的腺病毒,该腺病毒可以进入细胞,但不能在细胞内复制或引起疾病。
The Johnson & Johnson vaccine is based on the virus’s genetic instructions for building the spike protein. But unlike the Pfizer-BioNTech and Moderna vaccines, which store the instructions in single-stranded RNA, the Johnson & Johnson vaccine uses double-stranded DNA.
DNA Inside an Adenovirus
The researchers added the gene for the coronavirus spike protein to another virus called Adenovirus 26. Adenoviruses are common viruses that typically cause colds or flu-like symptoms. The Johnson & Johnson team used a modified adenovirus that can enter cells but can’t replicate inside them or cause illness.