Ralph Baric, Vineet Menachery and colleagues characterize a SARS-like coronavirus circulating in Chinese horseshoe bats to determine its potential to infect primary human airway epithelial cells, cause disease in mice and respond to available therapeutics.
了解cross species propensity and the molecular mechanisms is a key step to understand virus binding, attachment and fusion processes.
This is obviously an evolutionary event rather than man-made event. The evidence form virus genome sequence is not only compelling but validated by multiple institutions. It is likely the virus has infected an intermediate host for years before jump to human, just like MERS does.